Morphea and Eosinophilic Fasciitis: An Update

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Morphea and Eosinophilic Fasciitis: An Update

Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. The spectrum ranges from relatively mild phenotypes, which generally cause few problems besides local discomfort and visible disfigurement, to subtypes with severe complications such as joint contractures and limb length discrepancies. Eosinophilic fasciitis (EF, Shulman syndrome) is often r...

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Association of eosinophilic fasciitis with morphea.

Eosinophilic fasciitis is a rare inflammatory disease of unknown etiology, described for the first time by Shulman in 1974. The disease presents with induration of the skin, connective tissue and the underlying muscle fascia, sometimes accompanied by myalgia, most commonly in the lower extremities. Unlike scleroderma, it presents with absence of visceral organ involvement and Raynaud's phenomen...

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Fasciitis associated with generalized morphea.

Figure 1. Photograph of the legs. A large, thickened, firm, hyper/hypopigmented plaque is evident on the left leg. Figure 2. Biopsies of affected skin (A) and contiguous tibialis anterior muscle and fascia from the left leg (B–D). (A) The der-mal collagen is thickened, packed, and hyalinized. The subcutaneous fat is extensively replaced by collagen, and perivascular inflammatory infiltrates are...

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Eosinophilic fasciitis*

Eosinophilic fasciitis is a rare sclerodermiform syndrome of unknown etiology. It is characterized by the thickening of the muscular fascia and subcutaneous tissue, with a variable infiltration of eosinophils. Peripheral eosinophilia, poly or monoclonal hypergammaglobulinemia and increased erythrocyte sedimentation rate can be seen. Clinical features begin acutely, with local edema and a painfu...

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Eosinophilic fasciitis: an uncommon cause of edema.

Rapid clinical diagnosis is important as it will reassure patients and avoid unnecessary tests and studies and inappropriate treatment. While the association between pachydermodactyly and psychiatric morbidity is uncommon, given its importance, we believe that all patients diagnosed with pachydermodactyly should be evaluated by a psychiatrist, and particularly those who repeatedly interlock or ...

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ژورنال

عنوان ژورنال: American Journal of Clinical Dermatology

سال: 2017

ISSN: 1175-0561,1179-1888

DOI: 10.1007/s40257-017-0269-x